Activation Energies for Water Diffusion in ex-vivo White Matter
نویسندگان
چکیده
Introduction: Diffusion in brain tissue is well known to be non-Gaussian, resulting in major efforts to understand the biophysical basis of water mobility in such tissues [1]. This study aims to understand the energetics of differently diffusing components by quantification of their respective activation energies. When temperature is varied, self-diffusion in pure liquids follows the Arrhenius law, D(T)=D0 exp(-Ea/RT), where Ea is the activation energy for diffusion D(T), and R is the universal gas constant [2]. This equation can be fitted for each diffusion component.
منابع مشابه
Cortical Depth Dependence of the Diffusion Anisotropy in the Human Cortical Gray Matter In Vivo
Diffusion tensor imaging (DTI) is typically used to study white matter fiber pathways, but may also be valuable to assess the microstructure of cortical gray matter. Although cortical diffusion anisotropy has previously been observed in vivo, its cortical depth dependence has mostly been examined in high-resolution ex vivo studies. This study thus aims to investigate the cortical depth dependen...
متن کاملMicrostructure Imaging of Crossing (MIX) White Matter Fibers from diffusion MRI
Diffusion MRI (dMRI) reveals microstructural features of the brain white matter by quantifying the anisotropic diffusion of water molecules within axonal bundles. Yet, identifying features such as axonal orientation dispersion, density, diameter, etc., in complex white matter fiber configurations (e.g. crossings) has proved challenging. Besides optimized data acquisition and advanced biophysica...
متن کاملEx vivo evaluation of ADC values within spinal cord white matter tracts.
BACKGROUND AND PURPOSE Our purpose was to evaluate the effect of fixative on apparent diffusion coefficient (ADC) values and anisotropy within spinal cord white matter. As glutaraldehyde (GL) better preserves axonal ultrastructure as compared with paraformaldehyde (PF), we hypothesize that spinal cord white matter fixed with GL will have increased anisotropic water diffusion as compared with sp...
متن کاملThe Benefits and implementations of Diffusion tensor imaging and Neural Fiber Tractography in Brain Surgery
Background and Aim: The methods for detecting brain activation with fMRI, MRI provides a way to measure the anatomical connections which enable lightning-fast communication among neurons that specialize in different kinds of brain functions. Diffusion tensor imaging is able to measure the direction of bundles of the axonal fibers which are all aligned. Besides mapping white matter fiber tracts,...
متن کاملImage contrast using the secondary and tertiary eigenvectors in diffusion tensor imaging.
Diffusion tensor imaging (DTI) is a new imaging modality that can provide unique information on brain white matter anatomy. Measurements of water diffusion constant along multiple axes are fitted to a tensor model, from which the diffusion anisotropy and dominant fiber orientation can be estimated. Even though the tensor model is an oversimplification of the underlying neuroanatomy, information...
متن کامل